6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

Base Information

Chemical Name:6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester
CAS No.:165804-11-5
Molecular Formula:C₂₇H₃₁N₅O₄
Molecular Weight:489.574
Hs Code.:

6-(8-hydroxy-7,8-dihydro-6<i>H</i>-imidazo[4,5-<i>d</i>][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

Synonyms:6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

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Chemical Property of 6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

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Technology Process of 6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

There total 5 articles about 6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 165804-10-4
2-[4-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-butyl]-2-methyl-malonic acid monobenzyl ester

: 165804-11-5
6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1021/jm9905413

Reference yield:

: 72079-77-7
6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one

: 165804-11-5
6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH; NaI / dimethylformamide

2: NaBH₄ / methanol; CH₂Cl₂

3: aq. NaOH / dioxane / 8 h / 0 - 20 °C

4: Et₃N; diphenyl phosphorazidate / dimethylformamide / 8 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; diphenyl phosphoryl azide; sodium hydride; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction / 3: Hydrolysis / 4: Amidation;
DOI:10.1021/jm9905413

Reference yield:

: 2-(4-bromo-butyl)-2-methyl-malonic acid dibenzyl ester

: 165804-11-5
6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-2-methyl-2-phenylcarbamoyl-hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH; NaI / dimethylformamide

2: NaBH₄ / methanol; CH₂Cl₂

3: aq. NaOH / dioxane / 8 h / 0 - 20 °C

4: Et₃N; diphenyl phosphorazidate / dimethylformamide / 8 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; diphenyl phosphoryl azide; sodium hydride; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction / 3: Hydrolysis / 4: Amidation;
DOI:10.1021/jm9905413