1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

Base Information

• Chemical Name: 1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine
• CAS No.: 88609-66-9
• Molecular Formula: C₂₇H₂₈N₂O₂
• Molecular Weight: 412.532
• Mol file: 88609-66-9.mol

Synonyms:1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

Chemical Property of 1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

There total 6 articles about 1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,5-Bis-4-(2,5-dioxo-1-methylcyclopentyl)toluene (88589-36-0) → 1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine (88609-66-9)

Guidance literature:

With anthracene; N,N,N,N-tetraethylammonium tetrafluoroborate; ascorbic acid; In N,N-dimethyl-formamide; for 7.5h; Mechanism; Product distribution; electrolysis with Hg cathode at -1.7 to -1.9 V vs. SCE; variation of additives, reaction time;

DOI:10.1021/jo00180a001

Reference yield: 44.0%

4-Benzyl-7-(benzylamino)-6,8b-dimethyl-3a-hydroxy-1-oxo-1,2,3,3a,4,8b-hexahydrocyclopentindole (88589-38-2) → 1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine (88609-66-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo00180a001

Reference yield: 32.0%

2,5-Bis-4-(2,5-dioxo-1-methylcyclopentyl)toluene (88589-36-0) → 4-Benzyl-7--6,8b-dimethyl-3a-hydroxy-1-oxo-1,2,3,3a,4,8b-hexahydrocyclopentindole (88589-37-1) + 1-Benzyl-8--6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine (88589-39-3) + 1-Benzyl-8-(benzylamino)-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine (88609-66-9)

Guidance literature:

With anthracene; N,N,N,N-tetraethylammonium tetrafluoroborate; In N,N-dimethyl-formamide; for 0.133333h; electrolysis with Hg cathode at -2.00 V vs. Pt, carbon rod as anode;

DOI:10.1021/jo00180a001

upstream raw materials:

4-Benzyl-7-(benzylamino)-6,8b-dimethyl-3a-hydroxy-1-oxo-1,2,3,3a,4,8b-hexahydrocyclopentindole

2,5-Bis-4-(2,5-dioxo-1-methylcyclopentyl)toluene

C₂₇H₂₈N₂O₆S₂

benzyl bromide

Downstream raw materials:

1-benzyl-7,8-bis(benzyloxy)-6,9-dimethyl-5,5-(ethylenedioxy)-2-oxo-1,2,3,4,5,6-hexahydro-1-benzazocine

1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

6,9-dimethyl-5,5-(ethylenedioxy)-7-hydroxy-8-methoxy-1-(p-tolylsulfonyl)-1,2,3,4,5,6-hexahydro-1-benzazocine

C₂₄H₂₉NO₅