1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

Base Information

Chemical Name:1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione
CAS No.:116438-04-1
Molecular Formula:C₃₄H₃₃NO₄
Molecular Weight:519.64
Hs Code.:

Synonyms:1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

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Chemical Property of 1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

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Technology Process of 1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

There total 5 articles about 1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-39-0
benzyl bromide

: 116438-02-9
1-benzyl-7,8-dihydroxy-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

: 116438-04-1
1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In acetone; for 2.5h; Heating;
DOI:10.1021/jo00257a031

Reference yield:

: 116437-99-1
8-amino-1-benzyl-6,9-dimethyl-2,5-dioxo-1,2,3,4,5,6-hexahydro-1-benzazocine

: 116438-04-1
1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / CH₂Cl₂ / 0.25 h / 0 °C

2: 95 percent / 60percent aq. perchloric acid / tetrahydrofuran; CH₂Cl₂ / 0.17 h / 0 °C

3: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 0.5 h

4: 92 percent / K₂CO₃, 18-crown-6 / acetone / 2.5 h / Heating

With perchloric acid; 18-crown-6 ether; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jo00257a031

Reference yield:

: 116438-01-8
1-benzyl-6,9-dimethyl-2,5,7,8-tetraoxo-1,2,3,4,5,6,7,8-1-benzazocine

: 116438-04-1
1-Benzyl-7,8-bis-benzyloxy-6,9-dimethyl-1,3,4,6-tetrahydro-benzo[b]azocine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 0.5 h

2: 92 percent / K₂CO₃, 18-crown-6 / acetone / 2.5 h / Heating

With 18-crown-6 ether; hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; acetone;
DOI:10.1021/jo00257a031