8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt

Base Information

Chemical Name:8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt
CAS No.:1616830-75-1
Molecular Formula:C₁₉H₂₀N₄O₄S
Molecular Weight:400.458
Hs Code.:

Synonyms:8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt

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Chemical Property of 8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt

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Technology Process of 8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt

There total 6 articles about 8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1616830-77-3
6-(3-(4-methylpiperazin-1-ylsulfonyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

: 1616830-75-1
8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1616828-60-4
6-bromo-8-(2-trimethylsilanyl-ethoxymethoxy)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-quinazolin-4-one

: 1616830-75-1
8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1215634-37-9
4-bromo-2-carboxy-6-methoxybenzenamine hydrobromide

: 1616830-75-1
8-hydroxy-6-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3H-quinazolin-4-one trifluoro-acetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1: 12 h / 150 °C

2: hydrogen bromide; water / acetic acid / 96 h / 130 °C

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 80 °C / Cooling with ice

4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C

6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; hydrogen bromide; potassium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;