5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile

Base Information

Chemical Name:5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile
CAS No.:1260432-22-1
Molecular Formula:C₂₃H₁₉N₅O
Molecular Weight:381.437
Hs Code.:

Synonyms:5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile

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Chemical Property of 5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile

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Technology Process of 5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile

There total 6 articles about 5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 402718-29-0
3-cyanopyridine-5-boronic acid pinacol ester

: 1260432-92-5
2-(3-bromophenyl)-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-4-amine

: 1260432-22-1
5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile

Guidance literature:: With water; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 2h;

Reference yield:

: 874-90-8
4-methoxybenzonitrile

: 1260432-22-1
5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C

1.2: 0.5 h / -78 - 20 °C

2.1: ethanol / 2 h / 165 °C / Microwave irradiation; Sealed tube

3.1: tetrahydrofuran / 24 h / 60 °C

4.1: zinc(II) iodide / bis-triphenylphosphine-palladium(II) chloride / diethyl ether; tetrahydrofuran / 0 - 50 °C

5.1: water; sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 2 h / 80 °C

With n-butyllithium; water; sodium carbonate; zinc(II) iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1260432-22-1
5-(3-(4-amino-2-(4-methoxyphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C

1.2: 0.5 h / -78 - 20 °C

2.1: ethanol / 2 h / 165 °C / Microwave irradiation; Sealed tube

3.1: tetrahydrofuran / 24 h / 60 °C

4.1: zinc(II) iodide / bis-triphenylphosphine-palladium(II) chloride / diethyl ether; tetrahydrofuran / 0 - 50 °C

5.1: water; sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 2 h / 80 °C

With n-butyllithium; water; sodium carbonate; zinc(II) iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol;