2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

Base Information

Chemical Name:2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol
CAS No.:1616406-41-7
Molecular Formula:C₁₇H₁₂ClF₆N₃O
Molecular Weight:423.745
Hs Code.:

Synonyms:2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

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Chemical Property of 2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

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Technology Process of 2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

There total 2 articles about 2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.7%

: 129322-87-8
2-bromo-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-one

: 10057-46-2
6-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine

: 1616406-41-7
2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

: 1616405-94-7
2-(2-amino-6-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

Guidance literature:: 2-bromo-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-one; 6-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm500535j

Reference yield:

: 129322-81-2
1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-one

: 1616406-41-7
2-(2-amino-5-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

: 1616405-94-7
2-(2-amino-6-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloroform / 16 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With potassium carbonate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm500535j