(+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

Base Information

Chemical Name:(+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester
CAS No.:898530-58-0
Molecular Formula:C₃₄H₄₁BrN₂O₆Si
Molecular Weight:681.699
Hs Code.:

(+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

Synonyms:(+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

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Chemical Property of (+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

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Technology Process of (+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

There total 10 articles about (+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 898530-73-9
(+)-(Z)-3-[(3S)-7-benzyloxy-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

: 898530-58-0
(+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; at 0 ℃; for 0.333333h;
DOI:10.1021/ja0619455

Reference yield:

: 898530-54-6
(-)-(2S)-1-(4-benzyloxy-2,6-dibromophenyl)-3-chloropropan-2-ol

: 898530-58-0
(+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 12.8 g / NaN₃ / dimethylformamide / 9 h / 90 °C

2: 15.0 g / imidazole; DMAP / dimethylformamide / 6 h / 50 °C

3: tetrahydrofuran / 0.5 h / 20 °C

4: water / tetrahydrofuran / 2 h / 20 °C

5: 16.4 g / sodium bicarbonate / tetrahydrofuran; H₂O / 42 h / 20 °C

6: 83 percent / copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 60 °C

7: 89 percent / lithium chloride; triethylamine / Pd₂(dba)3; 2-di(tert-butyl)phosphine-1,1'-diphenyl / dimethylformamide / 1 h / 90 °C

8: 99 percent / cesium carbonate; thiophenol / acetonitrile / 0.5 h / 20 °C

9: 90 percent / N-bromosuccinimide / CH₂Cl₂ / 0.33 h / 0 °C

With 1H-imidazole; dmap; N-Bromosuccinimide; copper(l) iodide; sodium azide; water; cesium acetate; sodium hydrogencarbonate; caesium carbonate; thiophenol; triethylamine; lithium chloride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; johnphos; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 3: Staudinger reaction / 7: Heck reaction;
DOI:10.1021/ja0619455

Reference yield:

: 898530-71-7
(-)-(2S)-3-azido-1-(4-benzyloxy-2,6-bromophenyl)propan-2-ol

: 898530-58-0
(+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 15.0 g / imidazole; DMAP / dimethylformamide / 6 h / 50 °C

2: tetrahydrofuran / 0.5 h / 20 °C

3: water / tetrahydrofuran / 2 h / 20 °C

4: 16.4 g / sodium bicarbonate / tetrahydrofuran; H₂O / 42 h / 20 °C

5: 83 percent / copper iodide; cesium acetate / dimethylsulfoxide / 24 h / 60 °C

6: 89 percent / lithium chloride; triethylamine / Pd₂(dba)3; 2-di(tert-butyl)phosphine-1,1'-diphenyl / dimethylformamide / 1 h / 90 °C

7: 99 percent / cesium carbonate; thiophenol / acetonitrile / 0.5 h / 20 °C

8: 90 percent / N-bromosuccinimide / CH₂Cl₂ / 0.33 h / 0 °C

With 1H-imidazole; dmap; N-Bromosuccinimide; copper(l) iodide; water; cesium acetate; sodium hydrogencarbonate; caesium carbonate; thiophenol; triethylamine; lithium chloride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; johnphos; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 2: Staudinger reaction / 6: Heck reaction;
DOI:10.1021/ja0619455