898530-54-6

Basic information

• Product Name: (-)-(2S)-1-(4-benzyloxy-2,6-dibromophenyl)-3-chloropropan-2-ol
• Synonyms: (-)-(2S)-1-(4-benzyloxy-2,6-dibromophenyl)-3-chloropropan-2-ol
• CAS NO: 898530-54-6
• Molecular Weight: 434.555
• Mol File: 898530-54-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(2S)-1-(4-benzyloxy-2,6-dibromophenyl)-3-chloropropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(2S)-1-(4-benzyloxy-2,6-dibromophenyl)-3-chloropropan-2-ol(898530-54-6)
• EPA Substance Registry System: (-)-(2S)-1-(4-benzyloxy-2,6-dibromophenyl)-3-chloropropan-2-ol(898530-54-6)

Safety Data

• Hazardous Substances Data: 898530-54-6(Hazardous Substances Data)

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 556038-43-8 3,5-dibromo-4-iodophenol benzyl ether 

Downstream Products

• 898530-69-3 (-)-methyl 3-[(8S)-4-benzyloxy-6-(5-benzyloxy-6-methoxy-1H-indol-2-yl)carbonyl-6,7,8,9-tetrahydro-8-methanesulfonyloxy-3H-pyrrolo[3,2-f]quinoline-2-yl]carbonyl-4-hydroxy-5-methoxy-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-thiocarboxylate 
• 898530-67-1 (-)-[(8S)-4-benzyloxy-3-benzyloxycarbonyl-2-methoxycarbonyl-8,9-dihydro-8-(tert-butyldimethylsilyloxy)pyrrolo[3,2-f]quinolin-6(7H)-yl](5-benzyloxy-6-methoxy-1H-indol-2-yl)methanone 
• 898530-81-9 (-)-[(8S)-4-benzyloxy-3-benzyloxycarbonyl-2-methoxycarbonyl-8,9-dihydro-8-(methanesulfonyloxy)pyrrolo[3,2-f]quinolin-6(7H)-yl](5-benzyloxy-6-methoxy-1H-indol-2-yl)methanone 
• 898530-57-9 (-)-(Z)-3-[(3S)-7-benzyloxy-1-(o-nitrobenzensulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester 
• 898530-68-2 (-)-(8S)-4-benzyloxy-6-(5-benzyloxy-6-methoxy-1H-indol-2-yl)carbonyl-6,7,8,9-tetrahydro-8-methanesulfonyloxy-3H-pyrrolo[3,2-f]quinoline-2-carboxylic acid 
• 898530-58-0 (+)-(Z)-3-[(3S)-7-benzyloxy-6-bromo-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester 
• 898530-73-9 (+)-(Z)-3-[(3S)-7-benzyloxy-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinolin-5-yl]-2-(benzyloxycarbonylamino)acrylic acid methyl ester 
• 898530-51-3 (+)-(S)-3-benzyl-2-methyl-4-benzyloxy-6,7,8,9-tetrahydro-8-(tert-butyldimethylsilyloxy)pyrrolo[3,2-f]quinoline-2,3-dicarboxylate 
• 898530-55-7 (+)-[(2S)-3-(o-nitrobenzenesulfonylamino)-1-(4-benzyloxy-2,6-dibromophenyl)propan-2-yloxy](tert-butyl)dimethylsilane 
• 898530-56-8 (-)-(3S)-7-benzyloxy-5-bromo-1-(o-nitrobenzenesulfonyl)-1,2,3,4-tetrahydro-3-(tert-butyldimethylsilyloxy)quinoline 
• 898530-72-8 (+)-[(2S)-3-azido-1-(4-benzyloxy-2,6-dibromophenyl)propan-2-yloxy](tert-butyl)dimethylsilane 

Relevant articles and documents

Total synthesis of (+)-yatakemycin

A convergent total synthesis of (+)-yatakemycin was accomplished in a 20-step sequence in an overall yield of 13%. The synthesis features the regioselective ring opening of (S)-epichlorohydrin with 2,6-dibromophenyllithium species, the mild copper-mediated aryl amination utilizing the combination of CuI and CsOAc, and the efficient deprotection of benzyl groups of aryl benzyl ether with BCl3 in the presence of pentamethylbenzene. Copyright