ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

Base Information

Chemical Name:ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate
CAS No.:422323-08-8
Molecular Formula:C₃₉H₄₁F₂N₅O₉
Molecular Weight:761.779
Hs Code.:

ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

Synonyms:ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

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Chemical Property of ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

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Technology Process of ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

There total 14 articles about ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6332-56-5
2-hydroxy-3-nitropyridine

: 422323-08-8
ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: H₂ / 10percent Pd/C / ethanol / 16 h / 760.05 Torr

2.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

3.1: NaH / tetrahydrofuran / 0.33 h / 23 °C

3.2: 1.00 g / tetrahydrofuran / 16 h / Heating

4.1: 90 percent / aq. HF / acetonitrile / 4.5 h / 23 °C

5.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 23 °C

6.1: 0.363 g / tetrahydrofuran / 1.75 h / Heating

With hydrogen fluoride; hydrogen; sodium hydride; Dess-Martin periodane; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 33630-99-8
2-hydroxy-3-aminopyridine

: 422323-08-8
ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

2.1: NaH / tetrahydrofuran / 0.33 h / 23 °C

2.2: 1.00 g / tetrahydrofuran / 16 h / Heating

3.1: 90 percent / aq. HF / acetonitrile / 4.5 h / 23 °C

4.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 23 °C

5.1: 0.363 g / tetrahydrofuran / 1.75 h / Heating

With hydrogen fluoride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 223526-33-8
(1S,3'S)-<2-<1'-(2'',4''-dimethoxybenzyl)-2'-oxo-pyrrolidin-3'-yl>-1-hydroxymethylethyl>-carbamic acid tert-butyl ester

: 422323-08-8
ethyl trans-(2'S,3'''''S,4S)-4-(3'-(3'',4''-difluorophenyl)-2'-{3''',[(5''''-methylisoxazol-3''''-carbonyl)-amino]-2'''-oxo-2'''H-pyridin-1'''-yl}propionylamino)-5-[1'''''-(2'''''',4''''''-dimethoxybenzyl)-2'''''-oxopyrrolidin-3'''''-yl]pent-2-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 50 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 23 °C

2.1: HCl / dioxane / 1.25 h / 23 °C

3.1: 1.07 g / 4-methylmorpholine; HATU / acetonitrile / 2.5 h / 23 °C

4.1: N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / -10 °C

5.1: NaH / tetrahydrofuran / 0.33 h / 23 °C

5.2: 1.00 g / tetrahydrofuran / 16 h / Heating

6.1: 90 percent / aq. HF / acetonitrile / 4.5 h / 23 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 2 h / 23 °C

8.1: 0.363 g / tetrahydrofuran / 1.75 h / Heating

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen fluoride; sodium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k