(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Base Information

Chemical Name:(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate
CAS No.:1430738-44-5
Molecular Formula:C₃₂H₄₀FIN₂O₆Si
Molecular Weight:722.668
Hs Code.:

(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Synonyms:(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Chemical Property of (11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

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Technology Process of (11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

There total 13 articles about (11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 627-31-6
1,3-Diiodopropane

: 1430738-42-3
(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-hydroxy-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

: 1430738-44-5
(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: With potassium carbonate; In acetone; at 60 ℃; for 3h;

Reference yield:

: 1430738-05-8
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropyls11yl)oxy)benzoyl)pyrrolidin-3-one

: 1430738-44-5
(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

3.1: zinc; formic acid / ethanol / 0.5 h / 15 - 30 °C

4.1: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

5.1: acetic acid / methanol; water; tetrahydrofuran-d8 / 3 h / 20 °C

6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

7.1: 2,6-dimethylpyridine / dichloromethane / 1.16 h / 0 - 20 °C

8.1: lithium acetate; water / N,N-dimethyl-formamide / 2 h

9.1: potassium carbonate / acetone / 3 h / 60 °C

With pyridine; 2,6-dimethylpyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; oxalyl dichloride; lithium acetate; water; potassium carbonate; acetic acid; dimethyl sulfoxide; zinc; In 1,4-dioxane; methanol; tetrahydrofuran-d8; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 2.1: |Suzuki Coupling;

Reference yield:

: 1430738-04-7
((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

: 1430738-44-5
(11S,11aS)-allyl 11-((tert-butyldimethylsilyl)oxy)-2-(4-fluorophenyl)-8-(3-iodopropoxy)-7-methoxy-5-oxo-11,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.33 h / 0 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

4.1: zinc; formic acid / ethanol / 0.5 h / 15 - 30 °C

5.1: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

6.1: acetic acid / methanol; water; tetrahydrofuran-d8 / 3 h / 20 °C

7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

7.2: -78 - 20 °C / Inert atmosphere

8.1: 2,6-dimethylpyridine / dichloromethane / 1.16 h / 0 - 20 °C

9.1: lithium acetate; water / N,N-dimethyl-formamide / 2 h

10.1: potassium carbonate / acetone / 3 h / 60 °C

With pyridine; 2,6-dimethylpyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; oxalyl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; lithium acetate; water; potassium carbonate; acetic acid; dimethyl sulfoxide; zinc; In 1,4-dioxane; methanol; tetrahydrofuran-d8; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 3.1: |Suzuki Coupling;