((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

Base Information

Chemical Name:((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone
CAS No.:1430738-04-7
Molecular Formula:C₂₈H₅₀N₂O₇Si₂
Molecular Weight:582.885
Hs Code.:

Synonyms:((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

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Chemical Property of ((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

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Technology Process of ((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

There total 12 articles about ((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1430738-03-6
5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoic acid

: 260417-94-5
(2S,4R)-2-tert-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine

: 1430738-04-7
((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

Guidance literature:: 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 0.5h;

(2S,4R)-2-tert-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine; With triethylamine; In dichloromethane; at -10 - 20 ℃; Inert atmosphere;

Reference yield:

: 2454-72-0
6-nitrovanillin

: 1430738-04-7
((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / 0.08 h / 110 °C

2.1: dihydrogen peroxide; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate / tetrahydrofuran / 40 °C

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h

3.2: 1 h / 0 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1430738-02-5
5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzaldehyde

: 1430738-04-7
((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidin-1-yl)( 5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: dihydrogen peroxide; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate / tetrahydrofuran / 40 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h

2.2: 1 h / 0 °C / Inert atmosphere

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;