(+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

Base Information

Chemical Name:(+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole
CAS No.:1356335-46-0
Molecular Formula:C₂₂H₂₂F₂N₂
Molecular Weight:352.427
Hs Code.:

Synonyms:(+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

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Technology Process of (+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

There total 2 articles about (+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1356335-37-9
(+)-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

: 106-95-6
allyl bromide

: 1356335-46-0
(+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201101091

Reference yield:

: 35132-20-8
(R,R)-1,2-diphenylethylenediamine

: 110482-96-7
2,2-difluoro-4-pentenoic acid ethyl ester

: 1356335-46-0
(+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / hexane; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 70 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With trimethylaluminum; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201101091

Reference yield: 78.0%

: 1356335-46-0
(+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole

: 1356335-53-9
(-)-(2R,3R,6Z)-9,9-difluoro-3,5,8,9-tetrahydro-2,3-diphenyl-2H-imidazo[1,2-a]azepine

Guidance literature:: (+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole; With toluene-4-sulfonic acid; In dichloromethane; for 0.5h; Reflux; Inert atmosphere;

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃; for 0.5h; Reflux; Inert atmosphere;
DOI:10.1002/ejoc.201101091