Technology Process of C33H33F6NO6
There total 8 articles about C33H33F6NO6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(-)-(2R,3R)-1-benzyl-3-hydroxypiperidine-2-methanol; (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride;
With
dmap; triethylamine;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
With
silica gel;
In
diethyl ether; hexane;
DOI:10.1002/hlca.201100507
- Guidance literature:
-
Multi-step reaction with 4 steps
1: silica gel / hexane; ethyl acetate
2: Chiralcel.(R). OD / hexane; isopropyl alcohol
3: water; potassium hydroxide / ethanol / 3 h / 20 °C
4: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
dmap; water; silica gel; triethylamine; potassium hydroxide;
In
ethanol; hexane; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1002/hlca.201100507
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / -20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 °C
3.1: sodium tetrahydroborate / ethanol / -15 °C
3.2: -15 - 20 °C
4.1: Chiralcel.(R). OD / hexane; isopropyl alcohol
5.1: water; potassium hydroxide / ethanol / 3 h / 20 °C
6.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
pyridine; dmap; sodium tetrahydroborate; oxalyl dichloride; water; dimethyl sulfoxide; triethylamine; potassium hydroxide;
In
ethanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1002/hlca.201100507
