2-(Hydroxymethyl)pyridin-3-ol

Base Information

• Chemical Name: 2-(Hydroxymethyl)pyridin-3-ol
• CAS No.: 14047-53-1
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• Hs Code.: 2933399090
• European Community (EC) Number: 237-883-9
• NSC Number: 18473
• UNII: CC5XC2T8UZ
• DSSTox Substance ID: DTXSID00161408
• Nikkaji Number: J215.903A
• Wikidata: Q72481624
• ChEMBL ID: CHEMBL1367321
• Mol file: 14047-53-1.mol

Synonyms:2-(hydroxymethyl)pyridin-3-ol;14047-53-1;2-(Hydroxymethyl)-3-pyridinol;3-Hydroxypyridine-2-methanol;2-Pyridinemethanol, 3-hydroxy-;3-HYDROXY-2-PYRIDINEMETHANOL;CC5XC2T8UZ;MLS000737836;EINECS 237-883-9;NSC-18473;NSC241173;3-Hydroxy-2-pyridylmethanol;NSC18473;UNII-CC5XC2T8UZ;2-hydroxymethyl-3-pyridinol;Oprea1_379646;SCHEMBL1179397;CHEMBL1367321;DTXSID00161408;3-Hydroxy-2-hydroxymethylpyridine;HMS2884J19;BCP11425;MFCD00128114;NSC 18473;AKOS006228063;3-hydroxy-2-(hydroxy methyl)-pyridine;MB00702;s12139;2-HYDROXYMETHYL-3-HYDROXYPYRIDINE;NCGC00246765-01;BS-21405;SMR000528182;3-HYDROXY-2-(HYDROXYMETHYL)PYRIDINE;CS-0376840;FT-0649719;EN300-207842;A807654;AJ-333/25006072;J-509682

Chemical Property of 2-(Hydroxymethyl)pyridin-3-ol

Chemical Property:

• Vapor Pressure: 6.87E-07mmHg at 25°C
• Melting Point: 132 °C
• Refractive Index: 1.604
• Boiling Point: 393.2 °C at 760 mmHg
• PKA: 8.10±0.10(Predicted)
• Flash Point: 191.6 °C
• PSA: 53.35000
• Density: 1.318 g/cm³
• LogP: 0.27950
• Storage Temp.: Room temperature.
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 125.047678466
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-2-pyridinemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)CO)O

Technology Process of 2-(Hydroxymethyl)pyridin-3-ol

There total 6 articles about 2-(Hydroxymethyl)pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

pristinamycin IA (3131-03-1) → 2-methyl-3-pyridinol (1121-25-1,55780-69-3) + 3-hydroxy-2-hydroxymethylpyridine (14047-53-1) + <4-<1-des-(3-hydroxy-picolinoyl)-pristinamycin IA 1-oxalyl>-amino>-butyric acid + (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.06,10]hexacosane-2,5,11,14,18,21,24-heptaone (143381-36-6)

Guidance literature:

In sulfuric acid; at 25 ℃; controlled potential electrochem. reduction, (-)Hg/Pt(+), -1000 mV vs. s.c.e.;

DOI:10.1016/S0040-4020(01)80650-5

Reference yield: 41.0%

2-chloromethyl-3-hydroxypyridine hydrochloride (80322-74-3) → 3-hydroxy-2-hydroxymethylpyridine (14047-53-1)

Guidance literature:

With water;

Reference yield: 15.0%

pristinamycin IA (3131-03-1) → 3-hydroxy-2-hydroxymethylpyridine (14047-53-1) + (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.06,10]hexacosane-2,5,11,14,18,21,24-heptaone (143381-36-6) + 1-des-(3-hydroxy-picolinoyl)-1-<2-(3-hydroxypyridyl)>-methyl-pristinamycin IA

Guidance literature:

In sulfuric acid; at 25 ℃; controlled potential electrochem. reduction, (-)Hg/Pt(+), -850 mv Vs_. s.c.e.;

DOI:10.1016/S0040-4020(01)80650-5

upstream raw materials:

3-HYDROXYPYRIDINE

formaldehyd

3-acetoxy-2-acetoxymethyl-pyridine

2-chloromethyl-3-hydroxypyridine hydrochloride

Downstream raw materials:

2-(4-Bromo-phenylsulfanylmethyl)-pyridin-3-ol

2-Formyl-3-hydroxypyridin

3-Benzyloxy-2-(hydroxymethyl)pyridine

3-benzyloxy-2-benzyloxymethyl-6-iodopyridine