Technology Process of Fmoc-3-azido-O-(dibenzylphosphoryl)tyrosine
There total 5 articles about Fmoc-3-azido-O-(dibenzylphosphoryl)tyrosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Fmoc-3-azido-O-(dibenzylphosphoryl)tyrosine allyl ester;
With
N-methylaniline;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 20 ℃;
for 2h;
Inert atmosphere;
Darkness;
With
potassium hydrogensulfate;
In
tetrahydrofuran; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; water / pH 8.5
1.3: 0 - 20 °C
2.1: zinc; acetic acid / methanol / 1 h / 50 °C
3.1: potassium carbonate; triflic azide; copper(II) sulfate / dichloromethane; water; methanol / 20 °C / pH 8.5
4.1: 1H-tetrazole / tetrahydrofuran / 1 h / 20 °C
4.2: 0.17 h / 0 °C
5.1: N-methylaniline / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Darkness
With
1H-tetrazole; triflic azide; potassium carbonate; copper(II) sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; zinc;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; triflic azide; copper(II) sulfate / dichloromethane; water; methanol / 20 °C / pH 8.5
2.1: 1H-tetrazole / tetrahydrofuran / 1 h / 20 °C
2.2: 0.17 h / 0 °C
3.1: N-methylaniline / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Darkness
With
1H-tetrazole; triflic azide; potassium carbonate; copper(II) sulfate; N-methylaniline;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; water;
