5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N⁴-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoroamidite

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N⁴-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoroamidite
• CAS No.: 1037523-41-3
• Molecular Formula: C₅₆H₅₉N₆O₁₁P
• Molecular Weight: 1023.09

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N⁴-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoroamidite

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N⁴-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoroamidite

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N⁴-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoroamidite

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N⁴-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoroamidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N4-benzoylcytidine (1037523-34-4) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N4-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoroamidite (1037523-41-3)

Guidance literature:

With 4,5-dicyano-1H-imidazole; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jo800451m

upstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-phthalimidoethyl)-N⁴-benzoylcytidine

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

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