(2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

Base Information

Chemical Name:(2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester
CAS No.:1338919-52-0
Molecular Formula:C₁₈H₂₁NO₅
Molecular Weight:331.368
Hs Code.:

Synonyms:(2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

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Chemical Property of (2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

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Technology Process of (2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

There total 2 articles about (2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 56857-08-0
benzyl 1H-pyrrole-1-carboxylate

: 6295-06-3
butyl glyoxalate

: (2S)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

: 1338919-52-0
(2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

Guidance literature:: With titanium(IV) isopropylate; (R)-6,6'-dibromo-1,1'-binaphth-2-ol; In toluene; at 0 ℃; for 19h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol202244u

Reference yield:

: 344268-32-2,15763-01-6
dibutyl tartrate

: (2S)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

: 1338919-52-0
(2R)-2-[1-(benzyloxycarbonyl)-1H-pyrrol-2-yl]-2-hydroxyacetic acid n-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate

2: titanium(IV) isopropylate; (R)-6,6'-dibromo-1,1'-binaphth-2-ol / toluene / 19 h / 0 °C

With titanium(IV) isopropylate; sodium periodate; (R)-6,6'-dibromo-1,1'-binaphth-2-ol; In toluene; 2: Friedel Crafts alkylation;
DOI:10.1021/ol202244u