phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone

Base Information

• Chemical Name: phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone
• CAS No.: 6650-21-1
• Molecular Formula: C₂₂H₁₉N₃O
• Molecular Weight: 341.412
• Mol file: 6650-21-1.mol

Synonyms:phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone

Chemical Property of phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone

There total 3 articles about phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-benzoyl-4,9-dihydro-3H-β-carbolin-2-ium; chloride + pyrrole (109-97-7,30604-81-0) → phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone (6650-21-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1081/SCC-200026238

Reference yield:

3,4-dihydro-β-carboline (4894-26-2) → phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone (6650-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h / 0 °C

2: 35 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With triethylamine; In dichloromethane;

DOI:10.1081/SCC-200026238

Reference yield:

benzoyl chloride (98-88-4) → phenyl-1-(1H-2-pyrrolyl)-2,3,4,9-tetrahydro-1H-β-carbolin-2-ylmethanone (6650-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h / 0 °C

2: 35 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With triethylamine; In dichloromethane;

DOI:10.1081/SCC-200026238

upstream raw materials:

pyrrole

3,4-dihydro-β-carboline

benzoyl chloride