8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine

Base Information

• Chemical Name: 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine
• CAS No.: 1360612-47-0
• Molecular Formula: C₁₃H₁₂ClN₅
• Molecular Weight: 273.725
• Mol file: 1360612-47-0.mol

Synonyms:8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine

Chemical Property of 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine

There total 1 articles about 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,2-diamino-3-chloro-pyrazinium mesitylenate (1360612-56-1) + 3,5-dimethylphenyl isothiocyanate (40046-30-8) → 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine (1360612-47-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 64.5%

4-(3-Aminopropyl)morpholine (123-00-2) + 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine (1360612-47-0) → N2-(3,5-dimethyl-phenyl)-N8-(3-morpholin-4-yl-propyl)-[1,2,4]triazolo[1,5-a]pyrazine-2,8-diamine (1360608-85-0)

Guidance literature:

at 130 ℃; for 12h; Sealed tube;

Reference yield: 10.4%

8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine (1360612-47-0) + 3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)phenylamine (133303-88-5) → N8-{3-chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-N2-(3,5-dimethyl-phenylamino) [1,2,4]triazolo[1 ,5a]pyrazine-2,8-diamine

Guidance literature:

8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(3,5-dimethyl-phenyl)amine; 3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)phenylamine; With lithium hexamethyldisilazane; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; at 150 ℃; for 0.75h; Microwave irradiation;

With methanol; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

1,2-diamino-3-chloro-pyrazinium mesitylenate

3,5-dimethylphenyl isothiocyanate

Downstream raw materials:

N₂-(3,5-dimethyl-phenyl)-N₈-(3-morpholin-4-yl-propyl)-[1,2,4]triazolo[1,5-a]pyrazine-2,8-diamine

6-({2-[(3,5-dimethylphenyl)amino][1,2,4]triazolo[1,5-a]pyrazin-8-yl}amino)-2,2-difluoro-2H-1,4-benzoxazin-3(4H)-one