5-hydroxypentyl phenyl ketone

Base Information

• Chemical Name: 5-hydroxypentyl phenyl ketone
• CAS No.: 17851-49-9
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.258
• Mol file: 17851-49-9.mol

Synonyms:5-hydroxypentyl phenyl ketone

Chemical Property of 5-hydroxypentyl phenyl ketone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-hydroxypentyl phenyl ketone

There total 25 articles about 5-hydroxypentyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

phenyl(tetrahydro-2H-pyran-2-yl)methanone (73504-72-0) → 5-hydroxypentyl phenyl ketone (17851-49-9)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; for 0.25h;

DOI:10.1021/jo00110a008

Reference yield: 91.0%

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) + phenylmagnesium bromide (100-58-3) → 5-hydroxypentyl phenyl ketone (17851-49-9)

Guidance literature:

hexahydro-2H-oxepin-2-one; With sodium methylate; N,O-dimethylhydroxylamine*hydrochloride; In tetrahydrofuran; at -15 ℃; Inert atmosphere;

phenylmagnesium bromide; In tetrahydrofuran; at -15 - 20 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jacs.0c07854

Reference yield: 79.0%

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) + bromobenzene (108-86-1,52753-63-6) → 5-hydroxypentyl phenyl ketone (17851-49-9)

Guidance literature:

bromobenzene; With iodine; magnesium; In tetrahydrofuran; at 70 ℃; for 2h; Inert atmosphere;

hexahydro-2H-oxepin-2-one; With N,N-dimethylhydroxylamine hydrochloride; In tetrahydrofuran; at -15 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201800102

upstream raw materials:

1-phenyl-hexane-1,6-diol

N-bromoacetamide

phenyl(tetrahydro-2H-pyran-2-yl)methanone

5-(2-phenyl-[1,3]dioxolan-2-yl)-pentan-1-ol

Downstream raw materials:

ω-(4-Brom-benzolsulfonyloxy)-caprophenon

1-phenyl-hexane-1,6-diol

2-phenylhexahydrooxepine

6-oxo-6-phenylhexanal