Technology Process of 5-(tert-Butyldiphenylsilanyloxy)-3-methoxy-4-methylpentanal
There total 7 articles about 5-(tert-Butyldiphenylsilanyloxy)-3-methoxy-4-methylpentanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: CuI / tetrahydrofuran / 0.5 h / -20 °C
1.2: 66 percent / tetrahydrofuran / 2.5 h / -20 °C
2.1: 94 percent / imidazole / dimethylformamide / 20 °C
3.1: NaH / dimethylformamide / 0.08 h / 0 °C
3.2: 66 percent / dimethylformamide / 2 h / 20 °C
4.1: 92 percent / H2 / Pearlman's catalyst / methanol / 18 h
5.1: 87 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / 1.5 h / -78 °C
With
1H-imidazole; copper(l) iodide; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1.1: Transmetallation / 1.2: Methylation / 2.1: Substitution / 3.1: Metallation / 3.2: Methylation / 4.1: Hydrogenolysis / 5.1: Oxidation;
DOI:10.1039/b000751j
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Ti(O-i-Pr)4; (-)-diethyl tartrate; 4 Angstroem molecular sieves / CH2Cl2 / 0.5 h / -20 °C
1.2: 61 percent / t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / -20 °C
2.1: CuI / tetrahydrofuran / 0.5 h / -20 °C
2.2: 66 percent / tetrahydrofuran / 2.5 h / -20 °C
3.1: 94 percent / imidazole / dimethylformamide / 20 °C
4.1: NaH / dimethylformamide / 0.08 h / 0 °C
4.2: 66 percent / dimethylformamide / 2 h / 20 °C
5.1: 92 percent / H2 / Pearlman's catalyst / methanol / 18 h
6.1: 87 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / 1.5 h / -78 °C
With
1H-imidazole; titanium(IV) isopropylate; copper(l) iodide; oxalyl dichloride; 4 A molecular sieve; hydrogen; sodium hydride; dimethyl sulfoxide; (-)-diethyl tartrate; triethylamine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1.1: Substitution / 1.2: Epoxidation / 2.1: Transmetallation / 2.2: Methylation / 3.1: Substitution / 4.1: Metallation / 4.2: Methylation / 5.1: Hydrogenolysis / 6.1: Oxidation;
DOI:10.1039/b000751j
