301230-10-4Relevant academic research and scientific papers
Approaches towards the total synthesis of carolacton: Synthesis of C1-C16 fragment
Reddy, Sheri Venkata,Prasanna Kumar,Ramakrishna, Kallaganti V.S.,Sharma, Gangavaram V.M.
supporting information, p. 2018 - 2022 (2015/03/30)
Abstract A stereoselective synthesis of the C1-C16 segment of biofilm inhibitor carolacton has been achieved. The synthetic strategy involves Sharpless asymmetric epoxidation, Roush crotylation, Steglich esterification, RCM reaction and selective reduction of a disubstituted olefin in the presence of a trisubstituted olefin using in situ generated diimide.
A total synthesis of the unique tris-oxazole macrolide ulapualide a produced by the marine nudibranch Hexabranchus sanguineus
Chattopadhyay, Shital K.,Pattenden, Gerald
, p. 2429 - 2454 (2007/10/03)
A total synthesis of ulapualide A (1), whose relative stereochemistry was assigned on the basis of an earlier molecular mechanics study of its hypothetical metal chelated complex 9, is described. The synthesis is based on: i, elaboration of the double fun
Synthetic Studies towards Halichondramides, and Related Novel tris-Oxazole Containing Macrolides from Marine Organisms. A Concise Route to the Keto-triol Formyl Enamine Moiety.
Kiefel, Milton J.,Maddock, John,Pattenden, Gerald
, p. 3227 - 3230 (2007/10/02)
A synthesis of the keto-triol formyl enamine moiety (3) in the marine metabolite halichondramide (1) is described.The synthesis features judicious application of the Evans chiral aldol protocol in combination with the controlled ring opening of chiral α-e
