2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine

Base Information

Chemical Name:2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine
CAS No.:1586006-69-0
Molecular Formula:C₂₀H₂₂N₄O
Molecular Weight:334.421
Hs Code.:

Synonyms:2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine

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Chemical Property of 2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine

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Technology Process of 2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine

There total 3 articles about 2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3731-52-0
3-Aminomethylpyridine

: 2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyridin-4(5H)-one

: 1586006-69-0
2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; at 20 ℃; for 24h;
DOI:10.1124/dmd.113.052662

Reference yield:

: 856256-82-1
3-(phenoxymethyl)-1H-pyrazole-5-carboxylic acid ethyl ester

: 1586006-69-0
2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

2: potassium tert-butylate / toluene / 1.25 h / 20 °C / Reflux

3: lithium chloride; water / dimethyl sulfoxide / 12 h / 115 °C

4: acetic acid; sodium tris(acetoxy)borohydride / 24 h / 20 °C

With potassium tert-butylate; water; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; lithium chloride; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1124/dmd.113.052662

Reference yield:

: ethyl 1-(4-ethoxy-4-oxobutyl)-3-(phenoxymethyl)-1H-pyrazole-5-carboxylate

: 1586006-69-0
2-(phenoxymethyl)-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / toluene / 1.25 h / 20 °C / Reflux

2: lithium chloride; water / dimethyl sulfoxide / 12 h / 115 °C

3: acetic acid; sodium tris(acetoxy)borohydride / 24 h / 20 °C

With potassium tert-butylate; water; sodium tris(acetoxy)borohydride; acetic acid; lithium chloride; In dimethyl sulfoxide; toluene;
DOI:10.1124/dmd.113.052662