Technology Process of methyl 4-(6-fluoro-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate
There total 4 articles about methyl 4-(6-fluoro-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-(7-chloro-6-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)benzoate;
With
hydrogenchloride;
In
tetrahydrofuran; diethyl ether;
With
sodium iodide;
In
acetonitrile;
at 160 ℃;
for 0.5h;
Microwave irradiation;
With
sodium hydrogencarbonate; sodium thiosulfate;
In
water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 1 h / 20 °C
1.2: 0.08 h / 200 °C / Microwave irradiation
2.1: acetic acid; 3-chloro-benzenecarboperoxoic acid / 18 h / 20 °C
2.2: 0.17 h / 90 °C / Microwave irradiation
3.1: hydrogenchloride / tetrahydrofuran; diethyl ether
3.2: 0.5 h / 160 °C / Microwave irradiation
With
hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 1 h / 20 °C
1.2: 0.08 h / 200 °C / Microwave irradiation
2.1: acetic acid; 3-chloro-benzenecarboperoxoic acid / 18 h / 20 °C
2.2: 0.17 h / 90 °C / Microwave irradiation
3.1: hydrogenchloride / tetrahydrofuran; diethyl ether
3.2: 0.5 h / 160 °C / Microwave irradiation
With
hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; acetonitrile;
![methyl 4-(7-chloro-6-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)benzoate](/Databaselist/images/loading.webp)
