212268-13-8

Basic information

• Product Name: 6-FLUORO-3,4-PYRIDINEDIAMINE
• Synonyms: 6-FLUORO-3,4-PYRIDINEDIAMINE;2,3-Pyridinediamine,5-fluoro-(9CI);5-Fluoro-2,3-diaminopyridine;5-fluoro-2,3-pyridinediaMine;2,3-PyridinediaMine,5-fluoro-
• CAS NO: 212268-13-8
• Molecular Formula: C₅H₆FN₃
• Molecular Weight: 127.1196432
• EINECS: 200-258-5
• Product Categories: PYRIDINE;AMINEPRIMARY
• Mol File: 212268-13-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 303.852 °C at 760 mmHg
• Flash Point: 137.565 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.50±0.49(Predicted)
• CAS DataBase Reference: 6-FLUORO-3,4-PYRIDINEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-3,4-PYRIDINEDIAMINE(212268-13-8)
• EPA Substance Registry System: 6-FLUORO-3,4-PYRIDINEDIAMINE(212268-13-8)

Safety Data

• Hazardous Substances Data: 212268-13-8(Hazardous Substances Data)

Usage

General Description

6-FLUORO-3,4-PYRIDINEDIAMINE is a chemical compound with the molecular formula C5H6FN3. It is a derivative of pyridine and is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. 6-FLUORO-3,4-PYRIDINEDIAMINE is a white solid with a density of 1.36 g/cm3 and a melting point of 179-181°C. It is a key building block in the synthesis of various biologically active molecules and is used in the pharmaceutical industry for the development of new drugs. Additionally, 6-FLUORO-3,4-PYRIDINEDIAMINE is also used in the production of dyes, pigments, and other specialty chemicals.

InChI:InChI=1/C5H6FN3/c6-3-1-4(7)5(8)9-2-3/h1-2H,7H2,(H2,8,9)

Upstream product

• 212268-12-7 2-amino-5-fluoro-3-nitropyridine 
• 7439-89-6 iron 
• 884495-37-8 2-chloro-5-fluoro-3-nitropyridine 
• 1364719-61-8 C₁₂H₁₂FN₃ 
• 1364719-53-8 C₁₂H₁₀FN₃O₂ 
• 885031-84-5 3-azido-5-fluoropyridin-2-amine hydrochloride 

Downstream Products

• 1069131-92-5 methyl 4-(7-chloro-6-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)benzoate 
• 1069131-93-6 methyl 4-(6-fluoro-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate 
• 1069131-94-7 4-(6-fluoro-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid 
• 1069132-06-4 6-fluoro-7-iodo-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine 
• 1069132-03-1 6-fluoro-7-(4-methoxyphenyl)-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3H-imidazo[4,5-b]pyridine 
• 1069131-96-9 6-fluoro-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine 
• 1069131-95-8 6-fluoro-7-iodo-2-[4-(morpholin-4-ylcarbonyl)phenyl]-3H-imidazo[4,5-b]pyridine 
• 1069131-78-7 6-fluoro-N-(3-methoxypropyl)-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine-7-carboxamide hydrochloride 
• 1533398-99-0 N-(4-fluoro-3-(6-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide 
• 1369766-24-4 2-{(1R,2S)-2-(3,5-difluorophenyl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}cyclopropyl}-6-fluoro-1H-imidazo[4,5-b]pyridine 
• 1069131-91-4 methyl 4-(6-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)benzoate 

Relevant articles and documents

Benzimidazole derivatives, their preparation and their application in medicine and pharmacology (by machine translation)

The invention relates to a new control or inhibit indocyanine 2, 3 - dioxygenase (IDO) activity of the benzimidazole derivatives, their preparation and their application in medicine and pharmacology. Specifically, the invention relates to a compound of general formula (I) compound of formula and its pharmaceutically acceptable salt, containing the compound or its pharmaceutically acceptable salt of the pharmaceutical composition, the use of the compound or its pharmaceutically acceptable salts for treating and/or preventing the relevance of the IDO-mediated disease, especially a tumor of the method and the compound or its pharmaceutically acceptable salts thereof. The invention also relates to the compound or its pharmaceutically acceptable salt or containing the compound or its pharmaceutically acceptable salts for the preparation of a pharmaceutical composition for treating and/or preventing the relevance of the IDO-mediated disease, in particular of the use of the drug in the tumor. Wherein the general formula (I) of each substituent is as defined in the specification. (by machine translation)

HETERO RING-FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT

Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein a group represented by the formula: is a group represented by the formula: R1 /s

CGRP RECEPTOR ANTAGONISTS

Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.