3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide

Base Information

Chemical Name:3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide
CAS No.:195821-94-4
Molecular Formula:C₂₈H₃₇NO₅Si
Molecular Weight:495.691
Hs Code.:

Synonyms:3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide

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Chemical Property of 3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide

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Technology Process of 3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide

There total 4 articles about 3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 195821-93-3
Diethyl-carbamic acid 3-methyl-6-(1,4,5-trimethoxy-naphthalen-2-yl)-2-trimethylsilanyl-phenyl ester

: 195821-94-4
3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide

: N,N-Diethyl-2-{[2-hydroxy-6-methyl-3-(1,4,5-trimethoxy-naphthalen-2-yl)-phenyl]-dimethyl-silanyl}-acetamide

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jo971123d

Reference yield:

: 107941-22-0
2-bromo-1,4,5-trimethoxynaphthalene

: 195821-94-4
3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Pd(PPh₃)4, K₃PO₄ / toluene; ethanol; H₂O / Heating

2: 1.) s-BuLi, TMEDA / 1.) THF, -98 deg C

3: 62 percent / LDA / tetrahydrofuran / Ambient temperature

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jo971123d

Reference yield:

: 195821-92-2
Diethyl-carbamic acid 5-methyl-2-(1,4,5-trimethoxy-naphthalen-2-yl)-phenyl ester

: 195821-94-4
3-(2-Hydroxy-4-methyl-3-trimethylsilanyl-phenyl)-1,4,8-trimethoxy-naphthalene-2-carboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) s-BuLi, TMEDA / 1.) THF, -98 deg C

2: 62 percent / LDA / tetrahydrofuran / Ambient temperature

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo971123d