3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine

Base Information

Chemical Name:3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine
CAS No.:194467-40-8
Molecular Formula:C₁₆H₁₁BrF₃N₃O₂S
Molecular Weight:446.247
Hs Code.:

Synonyms:3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine

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Chemical Property of 3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine

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Technology Process of 3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine

There total 8 articles about 3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-bromo-5-[1-(4-methylsulfanyl-phenyl)-4-trifluoromethyl-1H-imidazol-2-yl]-pyridine

: 194467-40-8
3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine

Guidance literature:: With Oxone; In methanol; water; at 20 ℃;
DOI:10.1021/jm0000719

Reference yield:

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 194467-40-8
3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: CH₂Cl₂ / 20 °C

2.1: NH₃(g) / CH₂Cl₂ / 1 h / 20 °C

3.1: trifluoroacetic anhydride; Et₃N / CH₂Cl₂ / 0 °C

4.1: sodium bis(trimethylsilyl) amide / tetrahydrofuran / 4 h / 25 °C

4.2: tetrahydrofuran / 4 h

5.1: NaHCO₃ / propan-2-ol / 4.5 h / 50 - 80 °C

6.1: p-toluenesulfonic acid monohydrate / toluene / 4 h / Heating

7.1: oxone / H₂O; methanol / 20 °C

With Oxone; ammonia; sodium hexamethyldisilazane; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; toluene; 1.1: Condensation / 2.1: Substitution / 3.1: Dehydration / 4.1: deprotonation / 4.2: Addition / 5.1: Alkylation / 6.1: Dehydration / 7.1: Oxidation;
DOI:10.1021/jm0000719

Reference yield:

: 5-bromonicotinoyl-1H-imidazole

: 194467-40-8
3-bromo-5-[1-[4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazol-2-yl]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: NH₃(g) / CH₂Cl₂ / 1 h / 20 °C

2.1: trifluoroacetic anhydride; Et₃N / CH₂Cl₂ / 0 °C

3.1: sodium bis(trimethylsilyl) amide / tetrahydrofuran / 4 h / 25 °C

3.2: tetrahydrofuran / 4 h

4.1: NaHCO₃ / propan-2-ol / 4.5 h / 50 - 80 °C

5.1: p-toluenesulfonic acid monohydrate / toluene / 4 h / Heating

6.1: oxone / H₂O; methanol / 20 °C

With Oxone; ammonia; sodium hexamethyldisilazane; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; toluene; 1.1: Substitution / 2.1: Dehydration / 3.1: deprotonation / 3.2: Addition / 4.1: Alkylation / 5.1: Dehydration / 6.1: Oxidation;
DOI:10.1021/jm0000719