{(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

Base Information

Chemical Name:{(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester
CAS No.:813445-36-2
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:

Synonyms:{(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

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Chemical Property of {(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

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Technology Process of {(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

There total 10 articles about {(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 813445-35-1
{(7R,8R)-8-hydroxymethyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

: 813445-36-2
{(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -65 - -60 ℃; for 0.5h;

{(7R,8R)-8-hydroxymethyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester; In dichloromethane; at -70 - -50 ℃; for 1h;

With triethylamine; In dichloromethane; at -50 - 0 ℃; for 1.41667h;

Reference yield: 98.0%

: C₁₇H₂₁NO₆

: 813445-36-2
{(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

Guidance literature:: C₁₇H₂₁NO₆; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -70 - -50 ℃; for 1.5h;

With triethylamine; In dichloromethane; at -50 - 0 ℃; for 1.41667h;

Reference yield:

: 813445-32-8
ethyl 7-oxo-1,4-dioxaspiro[4.5]decane-8-carboxylate

: 813445-36-2
{(7R,8R)-8-formyl-1,4-dioxa-spiro[4.5]dec-7-yl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / benzene / 2 h / Heating / reflux

2.1: sodium tris(acetoxy)borohydride; ethylene glycol; acetic acid / dichloromethane / 16 h / 0 - 20 °C

3.1: sodium t-butanolate / tetrahydrofuran / 5.5 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

4.2: 0.75 h

5.1: hydrogen / palladium dihydroxide / methanol / 48 h / 3102.97 Torr

6.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 °C

7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -70 - -50 °C

7.2: 1.42 h / -50 - 0 °C

With lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ethylene glycol; acetic acid; dimethyl sulfoxide; sodium t-butanolate; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; benzene;