[(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol

Base Information

Chemical Name:[(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol
CAS No.:813445-34-0
Molecular Formula:C₁₇H₂₅NO₃
Molecular Weight:291.39
Hs Code.:

Synonyms:[(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol

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Chemical Property of [(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol

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Technology Process of [(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol

There total 5 articles about [(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

: 813445-34-0
[(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol

Guidance literature:: 7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃;

With sodium sulfate; In tetrahydrofuran; diethyl ether; water;

Reference yield:

: 813445-33-9
(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

: 813445-34-0
[(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol

Guidance literature:: (7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1.5h;

With water; sodium sulfate; In tetrahydrofuran; diethyl ether; for 0.75h;

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 813445-34-0
[(7R,8R)-7-((R)-1-phenyl-ethylamino)-1,4-dioxa-spiro[4.5]dec-8-yl]-methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 49.5 h / -78 - 20 °C

2.1: water; acetic acid / 6 h / 60 °C

3.1: toluene-4-sulfonic acid / benzene / 2 h / Heating / reflux

4.1: acetic acid / benzene / 2 h / Heating / reflux

5.1: sodium tris(acetoxy)borohydride; ethylene glycol; acetic acid / dichloromethane / 16 h / 0 - 20 °C

6.1: sodium t-butanolate / tetrahydrofuran / 5.5 h / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1.5 h / 0 °C

7.2: 0.75 h

With lithium aluminium tetrahydride; water; sodium tris(acetoxy)borohydride; ethylene glycol; acetic acid; lithium hexamethyldisilazane; sodium t-butanolate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;