Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

Base Information

• Chemical Name: Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester
• CAS No.: 103655-45-4
• Molecular Formula: C₅₀H₄₄N₅O₇PS₂
• Molecular Weight: 922.034
• Mol file: 103655-45-4.mol

Synonyms:Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

Chemical Property of Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

There total 1 articles about Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) + N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester (103655-45-4)

Guidance literature:

With dapsone; In pyridine; for 6h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87448-2

Reference yield: 95.0%

Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester (103655-45-4) + triethylamine (121-44-8) → Thiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine (103655-47-6)

Guidance literature:

With pyridine; water; for 0.416667h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96778-X

Reference yield:

Dithiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester (103655-45-4) → N6-benzoyldeoxyadenosine S,S-diphenyl 3'-phosphorodithioate (84765-89-9)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 0 ℃; for 0.0833333h;

DOI:10.1016/S0040-4020(01)96778-X

upstream raw materials:

cyclohexylammonium S,S-diphenyl phosphorodithioate

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

Downstream raw materials:

N⁶-benzoyldeoxyadenosine S,S-diphenyl 3'-phosphorodithioate

Thiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester

Thiophosphoric acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester; compound with triethyl-amine

C₆₈H₆₁N₈O₁₄PS