Propylamine, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N-methyl-, hydrochloride

Base Information

• Chemical Name: Propylamine, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N-methyl-, hydrochloride
• CAS No.: 84584-73-6
• Molecular Formula: C₁₁H₂₆ClNSi*ClH
• Molecular Weight: 272.334
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID70233565
• Mol file: 84584-73-6.mol

Synonyms:84584-73-6;Propylamine, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N-methyl-, hydrochloride;1-Propanamine, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N-methyl-, hydrochloride;N-(2-Chloroethyl)-3-(diethylmethylsilyl)-N-methyl-propylamine hydrochloride;C11H26ClNSi.ClH;C11-H26-Cl-N-Si.Cl-H;DTXSID70233565;LS-125563

Chemical Property of Propylamine, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N-methyl-, hydrochloride

Chemical Property:

• Vapor Pressure: 0.0394mmHg at 25°C
• Boiling Point: 239.8°C at 760 mmHg
• Flash Point: 98.8°C
• PSA: 3.24000
• LogP: 4.46750
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 8
• Exact Mass: 271.1289818
• Heavy Atom Count: 15
• Complexity: 137

Purity/Quality:

1-PROPANAMINE, N-(2-CHLOROETHYL)-3-(DIETHYLMETHYLSILYL)-N-METHYL-, HYD ROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC[Si](C)(CC)CCCN(C)CCCl.Cl

Technology Process of Propylamine, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N-methyl-, hydrochloride

There total 2 articles about Propylamine, N-(2-chloroethyl)-3-(diethylmethylsilyl)-N-methyl-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

2-{[3-(Diethyl-methyl-silanyl)-propyl]-methyl-amino}-ethanol (84584-58-7) → (2-Chloro-ethyl)-[3-(diethyl-methyl-silanyl)-propyl]-methyl-amine; hydrochloride (84584-73-6)

Guidance literature:

With thionyl chloride; In chloroform; at 35 - 40 ℃; for 4h;

DOI:10.1007/BF00772158

Reference yield:

(3-chloro-propyl)-diethyl-methyl-silane (18279-97-5) → (2-Chloro-ethyl)-[3-(diethyl-methyl-silanyl)-propyl]-methyl-amine; hydrochloride (84584-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / Et₃N / butan-1-ol / 22 h / Heating

2: 13 percent / SOCl₂ / CHCl₃ / 4 h / 35 - 40 °C

With thionyl chloride; triethylamine; In chloroform; butan-1-ol;

DOI:10.1007/BF00772158

Reference yield:

(2-Chloro-ethyl)-[3-(diethyl-methyl-silanyl)-propyl]-methyl-amine; hydrochloride (84584-73-6) + methyl iodide (74-88-4) → Methyldiethyl-<3-(N-methyl-N-2-chloroethylamino)propyl>silane methiodide (84584-76-9)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) ether, 2.) ether, 35-40 deg C, 4 h; 20 deg C, 16 h;

DOI:10.1007/BF00772158

upstream raw materials:

2-{[3-(Diethyl-methyl-silanyl)-propyl]-methyl-amino}-ethanol

(3-chloro-propyl)-diethyl-methyl-silane

Downstream raw materials:

Methyldiethyl-<3-(N-methyl-N-2-chloroethylamino)propyl>silane methiodide