diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate

Base Information

Chemical Name:diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate
CAS No.:1245711-70-9
Molecular Formula:C₂₂H₂₃ClN₂O₄S
Molecular Weight:446.955
Hs Code.:

Synonyms:diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate

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Technology Process of diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate

There total 3 articles about diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1245712-14-4
N-(2-chlorobenzylidene)-4-methylbenzo[d]thiazol-2-amine

: 105-53-3
diethyl malonate

: 1245711-70-9
diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate

Guidance literature:: With QD-4; In dichloromethane; at 20 ℃; for 72h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chir.21986

Reference yield:

: 1477-42-5
4-methyl-1,3-benzothiazol-2-amine

: 1245711-70-9
diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / Reflux

2: C₂₈H₂₇Cl₂F₃N₄OS / 5,5-dimethyl-1,3-cyclohexadiene / 72 h / 20 °C

With C₂₈H₂₇Cl₂F₃N₄OS; In 5,5-dimethyl-1,3-cyclohexadiene; toluene; 2: Mannich reaction;
DOI:10.1002/ejoc.201100351

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 1245711-70-9
diethyl 2-((4-methylbenzo[d]thiazol-2-ylamino)(2-chlorophenyl)-methyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / Reflux

2: C₂₈H₂₇Cl₂F₃N₄OS / 5,5-dimethyl-1,3-cyclohexadiene / 72 h / 20 °C

With C₂₈H₂₇Cl₂F₃N₄OS; In 5,5-dimethyl-1,3-cyclohexadiene; toluene; 2: Mannich reaction;
DOI:10.1002/ejoc.201100351