N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide

Base Information

• Chemical Name: N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide
• CAS No.: 1007374-33-5
• Molecular Formula: C₁₁H₁₂BrF₃N₂O₂
• Molecular Weight: 341.128
• Mol file: 1007374-33-5.mol

Synonyms:N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide

Chemical Property of N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide

There total 5 articles about N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-N-methyl-5-(trifluoromethyl)benzene-1,2-diamine (1007374-32-4) + 2-methoxyacetic acid (625-45-6) → N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide (1007374-33-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

N-methyl-2-nitro-5-(trifluoromethyl)aniline (883992-67-4) → N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide (1007374-33-5)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / acetic acid / 6 h / 70 °C

2: tin(ll) chloride / methanol / 3 h / Heating / reflux

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 6 h / 20 °C

With bromine; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In methanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

4-bromo-N-methyl-2-nitro-5-(trifluoromethyl)aniline (1007374-31-3) → N-(5-bromo-2-(methylamino)-4-(trifluoromethyl)phenyl)-2-methoxyacetamide (1007374-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(ll) chloride / methanol / 3 h / Heating / reflux

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 6 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-N-methyl-5-(trifluoromethyl)benzene-1,2-diamine

2-methoxyacetic acid

N-methyl-2-nitro-5-(trifluoromethyl)aniline

4-bromo-N-methyl-2-nitro-5-(trifluoromethyl)aniline