(3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol

Base Information

• Chemical Name: (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol
• CAS No.: 322428-57-9
• Molecular Formula: C₃₆H₅₀O₇Si
• Molecular Weight: 622.874

Synonyms:(3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol

Chemical Property of (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol

There total 6 articles about (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S)-5-[(4R,6R)-4-((E)-2-phenylethenyl)-2,2-dimethyl-1,3-dioxan-6-yl]-4-p-methoxybenzyloxy-2-pentene (322428-47-7) → (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol (322428-57-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 77 percent / O₂; PdCl₂; Cu(OAc)2*H₂O / N,N-dimethyl-acetamide; H₂O / 19.5 h / 20 °C

2.1: 85 percent / PPTS / methanol / 6.5 h

3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

3.2: 98 percent / tetrahydrofuran / 14.67 h / 0 - 20 °C

4.1: OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

5.1: NaIO₄; sodium phosphate / tetrahydrofuran; H₂O / 0.42 h / 0 - 20 °C / pH 7

6.1: 134 mg / tetrahydrofuran; toluene / 0.2 h / -78 - 0 °C

7.1: 83 mg / OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 4.5 h / 20 °C

8.1: 129 mg / Et₃N; DMAP / CH₂Cl₂ / 13.83 h / 0 - 20 °C

With dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; copper diacetate; oxygen; pyridinium p-toluenesulfonate; sodium hydride; triethylamine; sodium phosphate; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; acetone; toluene; tert-butyl alcohol; 1.1: Wacker oxidation / 6.1: Tebbe olefination;

DOI:10.1016/S0040-4020(01)00593-2

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) + (R)-3-Methoxy-4-[(2R,4R,6R)-6-methoxy-4-(4-methoxy-benzyloxy)-6-methyl-tetrahydro-pyran-2-yl]-butane-1,2-diol (322428-98-8) → (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol (322428-57-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 13.83h;

DOI:10.1016/S0040-4020(01)00593-2

Reference yield:

(1E,3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-1-phenyl-3-hydroxy-1-butene (322428-51-3) → (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol (322428-57-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 98 percent / tetrahydrofuran / 14.67 h / 0 - 20 °C

2.1: OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

3.1: NaIO₄; sodium phosphate / tetrahydrofuran; H₂O / 0.42 h / 0 - 20 °C / pH 7

4.1: 134 mg / tetrahydrofuran; toluene / 0.2 h / -78 - 0 °C

5.1: 83 mg / OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 4.5 h / 20 °C

6.1: 129 mg / Et₃N; DMAP / CH₂Cl₂ / 13.83 h / 0 - 20 °C

With dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; sodium hydride; triethylamine; sodium phosphate; In tetrahydrofuran; dichloromethane; water; acetone; toluene; tert-butyl alcohol; 4.1: Tebbe olefination;

DOI:10.1016/S0040-4020(01)00593-2

upstream raw materials:

tert-butylchlorodiphenylsilane

(R)-3-Methoxy-4-[(2R,4R,6R)-6-methoxy-4-(4-methoxy-benzyloxy)-6-methyl-tetrahydro-pyran-2-yl]-butane-1,2-diol

(R)-2-Methoxy-3-[(2R,4R,6R)-6-methoxy-4-(4-methoxy-benzyloxy)-6-methyl-tetrahydro-pyran-2-yl]-propionaldehyde

(4S)-5-[(4R,6R)-4-((E)-2-phenylethenyl)-2,2-dimethyl-1,3-dioxan-6-yl]-4-p-methoxybenzyloxy-2-pentene

Downstream raw materials:

(3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butylamine

(3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butylazide

2'-((S,3E,6Z,9E)-6,8-dimethylundeca-3,6,9-trien-1-yl)-4-((R)-1-methoxy-2-((2R,4R,6R)-6-methoxy-4-((4-methoxybenzyl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)ethyl)-2,4'-bioxazole

(3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-2-[(3E,6Z,8S,9E)-2-(6,8-dimethyl-3,6,9-undecatrienyl)oxazole-4-carbonylamino]-3-methoxy-1-butanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 322428-57-9 (3R)-4-[(2R,4R,6R)-4-p-methoxybenzyloxy-2-methoxy-2-methyltetrahydropyran-6-yl]-3-methoxy-1-tert-butyldiphenylsiloxy-2-butanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send