(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

Base Information

Chemical Name:(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]
CAS No.:1067648-23-0
Molecular Formula:C₄₃H₅₇F₂N₅O₈S
Molecular Weight:842.017
Hs Code.:

(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

Synonyms:(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

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Chemical Property of (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

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Technology Process of (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

There total 10 articles about (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1067649-38-0
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

: 1067648-45-6
(2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

: 1067648-23-0
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: (1S,4S,5S)-3-oxo-2-oxa-bicyclo[2.2.1]heptane-5-carboxylic acid

: 1067648-23-0
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

Guidance literature:: Multi-step reaction with 9 steps

1.1: dichloromethane / 23 h

2.1: potassium carbonate / 0.5 h / 0 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.17 h / 0 °C

3.2: 2.33 h / 0 °C

4.1: water; triphenylphosphine / methanol / 23 h

5.1: pyridine / dichloromethane / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1.33 h

7.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

7.2: 2.5 h / 0 °C

8.1: lithium hydroxide; water; methyl iodide

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With pyridine; triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; water; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1067648-62-7
(1R,2R,4R)-1-tert-butyl 2-methyl 4-aminocyclopentane-1,2-dicarboxylate

: 1067648-23-0
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-cyclopentane-1,2-dicarboxylic acid 1-{[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluoro-benzyloxymethyl)-2-hydroxy-pentyl]-amide} 2-[((R)-1-phenyl-ethyl)-amide]

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1.33 h

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

3.2: 2.5 h / 0 °C

4.1: lithium hydroxide; water; methyl iodide

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With pyridine; triethylsilane; lithium hydroxide; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; methyl iodide; In dichloromethane; N,N-dimethyl-formamide;