(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid
CAS No.:1067649-38-0
Molecular Formula:C₁₇H₂₄N₂O₅S
Molecular Weight:368.454
Hs Code.:

Synonyms:(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

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Chemical Property of (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

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Technology Process of (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

There total 8 articles about (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067648-66-1
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester

: 1067649-38-0
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

Guidance literature:: (1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid methyl ester; With lithium hydroxide; water; methyl iodide;

With acetic acid; In ethyl acetate; toluene;

Reference yield:

: (1S,4S,5S)-3-oxo-2-oxa-bicyclo[2.2.1]heptane-5-carboxylic acid

: 1067649-38-0
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: dichloromethane / 23 h

2.1: potassium carbonate / 0.5 h / 0 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.17 h / 0 °C

3.2: 2.33 h / 0 °C

4.1: water; triphenylphosphine / methanol / 23 h

5.1: pyridine / dichloromethane / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1.33 h

7.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

7.2: 2.5 h / 0 °C

8.1: lithium hydroxide; water; methyl iodide

With pyridine; triethylsilane; lithium hydroxide; di-isopropyl azodicarboxylate; water; sodium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1067648-62-7
(1R,2R,4R)-1-tert-butyl 2-methyl 4-aminocyclopentane-1,2-dicarboxylate

: 1067649-38-0
(1R,2R,4S)-4-(methanesulphonyl(methyl)amino)-2-((R)-1-phenyl-ethylcarbamoyl)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1.33 h

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h

3.2: 2.5 h / 0 °C

4.1: lithium hydroxide; water; methyl iodide

With pyridine; triethylsilane; lithium hydroxide; water; sodium hydride; trifluoroacetic acid; methyl iodide; In dichloromethane; N,N-dimethyl-formamide;