5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid

Base Information

Chemical Name:5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid
CAS No.:1352836-52-2
Molecular Formula:C₃₀H₂₇ClN₄O₆
Molecular Weight:575.021
Hs Code.:

Synonyms:5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid

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Chemical Property of 5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid

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Technology Process of 5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid

There total 6 articles about 5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352836-50-0
methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

: 4506-45-0
5-chloro-ortho-formylbenzoic acid

: 1352836-52-2
5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane; Inert atmosphere;

Reference yield:

: 890434-95-4
methyl 6-(2-methoxyethoxy)-1H-indole-2-carboxylate

: 1352836-52-2
5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tin(IV) chloride / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 4.08 h

2.1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux

3.1: trichlorophosphate / 1 h / 100 °C / Inert atmosphere

3.2: Cooling with ice

4.1: sodium acetate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 90 °C / 3620.13 Torr / Inert atmosphere

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; tetrahydrofuran / Inert atmosphere

With sodium acetate; tin(IV) chloride; sodium tris(acetoxy)borohydride; hydrazine hydrate; acetic acid; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 116350-38-0
6-hydroxy-1H-indole-2-carboxylic acid methyl ester

: 1352836-52-2
5-chloro-2-((3-(4-(methoxycarbonyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indol-1-yl)-2-methylphenylamino)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

2.1: tin(IV) chloride / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

2.2: 4.08 h

3.1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux

4.1: trichlorophosphate / 1 h / 100 °C / Inert atmosphere

4.2: Cooling with ice

5.1: sodium acetate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 90 °C / 3620.13 Torr / Inert atmosphere

6.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; tetrahydrofuran / Inert atmosphere

With sodium acetate; tin(IV) chloride; sodium tris(acetoxy)borohydride; caesium carbonate; hydrazine hydrate; acetic acid; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;