methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

Base Information

Chemical Name:methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate
CAS No.:1352836-50-0
Molecular Formula:C₂₂H₂₂N₄O₄
Molecular Weight:406.441
Hs Code.:

Synonyms:methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

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Chemical Property of methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

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Technology Process of methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

There total 5 articles about methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1352836-48-6
4-chloro-7-(2-methoxyethoxy)-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indole

: 1352836-50-0
methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

Guidance literature:: With sodium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In N,N-dimethyl acetamide; at 90 ℃; under 3620.13 Torr; Inert atmosphere;

Reference yield:

: 890434-95-4
methyl 6-(2-methoxyethoxy)-1H-indole-2-carboxylate

: 1352836-50-0
methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tin(IV) chloride / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 4.08 h

2.1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux

3.1: trichlorophosphate / 1 h / 100 °C / Inert atmosphere

3.2: Cooling with ice

4.1: sodium acetate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 90 °C / 3620.13 Torr / Inert atmosphere

With sodium acetate; tin(IV) chloride; hydrazine hydrate; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 116350-38-0
6-hydroxy-1H-indole-2-carboxylic acid methyl ester

: 1352836-50-0
methyl 1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

2.1: tin(IV) chloride / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

2.2: 4.08 h

3.1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux

4.1: trichlorophosphate / 1 h / 100 °C / Inert atmosphere

4.2: Cooling with ice

5.1: sodium acetate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 90 °C / 3620.13 Torr / Inert atmosphere

With sodium acetate; tin(IV) chloride; caesium carbonate; hydrazine hydrate; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;