N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea

Base Information

• Chemical Name: N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea
• CAS No.: 1305317-39-8
• Molecular Formula: C₂₆H₁₈ClN₅O
• Molecular Weight: 451.915
• Mol file: 1305317-39-8.mol

Synonyms:N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea

Chemical Property of N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea

There total 7 articles about N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

8-amino-2,3-diphenylpyrido[2,3-b]pyrazine (1305317-35-4) + m-chlorophenyl isocyanate (2909-38-8) → N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea (1305317-39-8)

Guidance literature:

8-amino-2,3-diphenylpyrido[2,3-b]pyrazine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

m-chlorophenyl isocyanate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 7h;

DOI:10.1055/s-0030-1259429

Reference yield:

3-amino-2-nitropyridine (13269-19-7) → N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea (1305317-39-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium acetate; acetic acid / 1 h / 20 °C

1.2: 20 °C

2.1: tin(ll) chloride / ethanol; water / 2 h / Reflux

3.1: 1,4-dioxane / 120 h / Reflux

4.1: sodium azide / dimethyl sulfoxide / 1 h / Reflux

5.1: triphenylphosphine / tetrahydrofuran / 24 h / Reflux

5.2: 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

6.2: 7 h / 20 °C

With sodium azide; potassium acetate; sodium hydride; acetic acid; triphenylphosphine; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 5.1: Staudinger reaction / 5.2: Staudinger reaction;

DOI:10.1055/s-0030-1259429

Reference yield:

3-amino-4-bromo-2-nitropyridine (1305317-30-9) → N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea (1305317-39-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tin(ll) chloride / ethanol; water / 2 h / Reflux

2.1: 1,4-dioxane / 120 h / Reflux

3.1: sodium azide / dimethyl sulfoxide / 1 h / Reflux

4.1: triphenylphosphine / tetrahydrofuran / 24 h / Reflux

4.2: 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 7 h / 20 °C

With sodium azide; sodium hydride; triphenylphosphine; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 4.1: Staudinger reaction / 4.2: Staudinger reaction;

DOI:10.1055/s-0030-1259429

upstream raw materials:

3-amino-2-nitropyridine

3-amino-4-bromo-2-nitropyridine

2,3-diamino-4-bromopyridine

8-bromo-2,3-diphenylpyrido[2,3-b]pyrazine