ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

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Chemical Name:ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate
CAS No.:1316761-71-3
Molecular Formula:C₂₉H₂₈N₆O₅
Molecular Weight:540.579
Hs Code.:

Synonyms:ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

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Chemical Property of ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

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Technology Process of ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

There total 7 articles about ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1316761-72-4
diethyl 1-(2-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-2-oxoethyl)-1H-pyrazole-3,5-dicarboxylate

: 1316761-71-3
ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

Guidance literature:: With ammonium acetate; In ethanol; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 854391-95-0
bis(4-methoxybenzyl)amine hydrochloride

: 1316761-71-3
ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 160 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 22 h / 100 °C

2.2: 1 h

3.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 2 h / 0 °C

3.2: 1 h / 0 °C

4.1: potassium carbonate / acetone / 20 °C

5.1: ammonium acetate / ethanol / 1 h / 150 °C / Microwave irradiation

With trimethylsilyl trifluoromethanesulfonate; ammonium acetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1272403-00-5
5-bromo-N,N-bis[(4-methoxyphenyl)methyl]pyrimidin-2-amine

: 1316761-71-3
ethyl 6-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 22 h / 100 °C

1.2: 1 h

2.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 2 h / 0 °C

2.2: 1 h / 0 °C

3.1: potassium carbonate / acetone / 20 °C

4.1: ammonium acetate / ethanol / 1 h / 150 °C / Microwave irradiation

With trimethylsilyl trifluoromethanesulfonate; ammonium acetate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;