Bis(4-methoxybenzyl)amine hydrochloride

Base Information

• Chemical Name: Bis(4-methoxybenzyl)amine hydrochloride
• CAS No.: 854391-95-0
• Molecular Formula: C16H19NO2.ClH
• Molecular Weight: 293.793
• Hs Code.: 2922299090
• European Community (EC) Number: 826-609-9
• Mol file: 854391-95-0.mol

Synonyms:bis(4-methoxybenzyl)amine hydrochloride;854391-95-0;BIS(4-METHOXYBENZYL)AMINE HCL SALT;bis[(4-methoxyphenyl)methyl]amine hydrochloride;MFCD07170733;1-(4-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]methanamine;hydrochloride;Bis(4-methoxybenzyl)amine HCl;SCHEMBL2147064;AMY30359;bis(4-methoxybenzyl)aminehydrochloride;AKOS008039586;DS-9098;SB82452;SY115299;DB-307666;CS-0149517;EN300-68687;F70697;A863583;Z1263602456

Chemical Property of Bis(4-methoxybenzyl)amine hydrochloride

Chemical Property:

• Melting Point: 243-245 °C
• PSA: 30.49000
• LogP: 4.18650
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 293.1182566
• Heavy Atom Count: 20
• Complexity: 207

Purity/Quality:

99% ^*data from raw suppliers

Bis(4-methoxybenzyl)aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CNCC2=CC=C(C=C2)OC.Cl

Technology Process of Bis(4-methoxybenzyl)amine hydrochloride

There total 4 articles about Bis(4-methoxybenzyl)amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methoxy-benzaldehyde (123-11-5) + 4-methoxy-benzylamine (2393-23-9) → bis(4-methoxybenzyl)amine hydrochloride (854391-95-0)

Guidance literature:

4-methoxy-benzaldehyde; 4-methoxy-benzylamine; In ethanol; for 6h; Reflux;

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; water;

Reference yield: 64.0%

N,N-bis(p-methoxybenzyl)amine (17061-62-0) → bis(4-methoxybenzyl)amine hydrochloride (854391-95-0)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃;

DOI:10.1039/c4cc04668d

Reference yield:

N-(4-methoxybenzylidene)-4-methoxybenzylamine (3261-60-7) → bis(4-methoxybenzyl)amine hydrochloride (854391-95-0)

Guidance literature:

N-(4-methoxybenzylidene)-4-methoxybenzylamine; With sodium tetrahydroborate; In methanol; at 0 - 40 ℃; for 2h;

With hydrogenchloride; In water;

upstream raw materials:

N-(4-methoxybenzylidene)-4-methoxybenzylamine

4-methoxy-benzaldehyde

4-methoxy-benzylamine

N,N-bis(p-methoxybenzyl)amine

Downstream raw materials:

N,N-bis<(4-methoxyphenyl)methyl>ethenesulfonamide

5-bromo-N,N-bis[(4-methoxyphenyl)methyl]pyrimidin-2-amine

1-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)ethan-1-one

1-(2-(bis(4-methoxybenzyl)amino)pyrimidin-5-yl)-2-bromoethan-1-one

Refernces

• 1、 Payne, Nicholas A.,Delmas, Luke C.,McDowell, Sean A.C.,Williams, Avril R.. "Computationally forecasting the effect of dibenzylammonium substituents on pseudorotaxane formation with dibenzo[24]crown-8". supporting information. p. 5175 - 5179. Retrieved 2015/08/18.
• 2、 -. "NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS". Paragraph 0278; 0279; 0280. . Retrieved 2013/06/04.