3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl

Base Information

Chemical Name:3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl
CAS No.:130247-15-3
Molecular Formula:C₄₄H₄₈N₂O₁₀
Molecular Weight:764.873
Hs Code.:

Synonyms:3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl

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Chemical Property of 3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl

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Technology Process of 3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl

There total 3 articles about 3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 94882-75-4
benzyl (2-t-butoxycarbonylamino)acrylate

: 130247-00-6
3,3'-diiodo-4,4'-dimethoxybiphenyl

: 130247-15-3
3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl

Guidance literature:: With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide; at 85 ℃; for 16h;
DOI:10.1021/jo00003a065

Reference yield: 16.0%

: 94882-75-4
benzyl (2-t-butoxycarbonylamino)acrylate

: 130247-00-6
3,3'-diiodo-4,4'-dimethoxybiphenyl

: 130247-10-8
3-<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-3'-iodo-4,4'-dimethoxybiphenyl

: 130247-15-3
3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl

Guidance literature:: With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide; at 85 ℃; for 16h;
DOI:10.1021/jo00003a065

Reference yield:

: 2132-80-1
4,4'-Dimethoxybiphenyl

: 130247-15-3
3,3'-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4,4'-dimethoxybiphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: 1) BuLi, 2) iodine / 1) diethyl ether, hexane, r.t., 15 h, 2) diethyl ether, -70 deg C to r.t.

2: 16 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

With n-butyllithium; tetrabutyl-ammonium chloride; iodine; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00003a065