Technology Process of 8-Benzyloxy-2',3'-dideoxyadenosine
There total 8 articles about 8-Benzyloxy-2',3'-dideoxyadenosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetraethylammonium fluoride;
In
acetonitrile;
for 3h;
Ambient temperature;
DOI:10.1055/s-1990-27066
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N,N-dimethylaminopyridine, NEt3 / dimethylformamide; CH2Cl2 / 12 h / Ambient temperature
2: dimethylformamide / 6 h / Ambient temperature
3: tributyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 2.5 h / Heating
4: dimethylformamide / 5 h / 90 °C
5: tributyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 1.5 h / Heating
6: 82 percent / Et4NF / acetonitrile / 3 h / Ambient temperature
With
dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tetraethylammonium fluoride; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1055/s-1990-27066
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dimethylformamide / 5 h / 90 °C
2: tributyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 1.5 h / Heating
3: 82 percent / Et4NF / acetonitrile / 3 h / Ambient temperature
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tetraethylammonium fluoride;
In
N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1055/s-1990-27066
