N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide

Base Information

Chemical Name:N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide
CAS No.:1314020-77-3
Molecular Formula:C₂₂H₂₄N₆O₈S₂
Molecular Weight:564.6
Hs Code.:

Synonyms:N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide

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Chemical Property of N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide

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Technology Process of N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide

There total 6 articles about N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1314020-55-7
N-[(prop-2-yn-1-yl-amino)carbonyl]benzenesulfonamide

: 1314020-67-1
4-[(4-azidophenyl)sulfonyl]-N-hydroxytetrahydro-2H-pyran-4-carboxamide

: 1314020-77-3
N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; Inert atmosphere;
DOI:10.1039/c0ob00852d

Reference yield:

: 1314020-62-6
4-[(4-nitrophenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxylic acid

: 1314020-77-3
N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; water / 5 h / 20 °C / 3102.97 Torr

2: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 0 - 20 °C / Inert atmosphere

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

5: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 5: Huisgen 1,3-dipolar cycloaddition;
DOI:10.1039/c0ob00852d

Reference yield:

: 1314020-64-8
4-[(4-azidophenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxylic acid

: 1314020-77-3
N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; copper(ll) sulfate pentahydrate; benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: Huisgen 1,3-dipolar cycloaddition;
DOI:10.1039/c0ob00852d