4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide

Base Information

Chemical Name:4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide
CAS No.:1314020-65-9
Molecular Formula:C₁₇H₂₂N₄O₆S
Molecular Weight:410.451
Hs Code.:

Synonyms:4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide

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Chemical Property of 4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide

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Technology Process of 4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide

There total 5 articles about 4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1314020-64-8
4-[(4-azidophenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxylic acid

: 1314020-65-9
4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/c0ob00852d

Reference yield:

: 1314020-61-5
methyl 4-[(4-nitrophenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxylate

: 1314020-65-9
4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol; water / 5 h / 20 °C / 3102.97 Torr

3: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 0 - 20 °C / Inert atmosphere

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; tert.-butylnitrite; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c0ob00852d

Reference yield:

: 1314020-63-7
4-[(4-aminophenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxylic acid

: 1314020-65-9
4-[(4-azidophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 0 - 20 °C / Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; tert.-butylnitrite; trimethylsilylazide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c0ob00852d