2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol

Base Information

Chemical Name:2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol
CAS No.:161447-05-8
Molecular Formula:C₂₀H₂₀ClNO₂S
Molecular Weight:373.903
Hs Code.:

Synonyms:2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol

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Chemical Property of 2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol

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Technology Process of 2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol

There total 3 articles about 2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155143-17-2
ethyl <1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>acetate

: 161447-05-8
2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jm00034a013

Reference yield:

: [5-Allyloxy-3-tert-butylsulfanyl-1-(4-chloro-benzyl)-1H-indol-2-yl]-acetic acid ethyl ester

: 161447-05-8
2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

2: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1021/jm00034a013

Reference yield:

: 1-(4-chlorobenzyl)-1-(4-allyloxy phenyl)hydrazine hydrochloride

: 161447-05-8
2-<1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: AcONa, AcOH / toluene / 1.5 h / 70 °C

2: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

3: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; sodium acetate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jm00034a013