(S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate

Base Information

Chemical Name:(S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate
CAS No.:1281895-86-0
Molecular Formula:C₂₅H₃₂N₂O₇
Molecular Weight:472.538
Hs Code.:

Synonyms:(S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate

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Chemical Property of (S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate

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Technology Process of (S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate

There total 6 articles about (S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₆N₂O₅

: 501-53-1,94274-21-2
benzyl chloroformate

: 1281895-86-0
(S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/ol400136y

Reference yield:

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 1281895-86-0
(S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / Reflux

2: zinc(II) oxide / toluene / 24 h / Reflux

3: potassium carbonate / acetone / 24 h / 40 °C

4: europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine / acetonitrile / 48 h / -20 °C / Molecular sieve; Inert atmosphere

5: trifluoroacetic acid

6: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

With sodium hydride; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; zinc(II) oxide; europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; In tetrahydrofuran; acetone; toluene; acetonitrile; mineral oil; 4: |Michael Addition;
DOI:10.1021/ol400136y

Reference yield:

: 74053-93-3
methyl 3-(3,4-dimethoxyphenyl)-3-oxopropionate

: 1281895-86-0
(S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: zinc(II) oxide / toluene / 24 h / Reflux

2: potassium carbonate / acetone / 24 h / 40 °C

3: europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine / acetonitrile / 48 h / -20 °C / Molecular sieve; Inert atmosphere

4: trifluoroacetic acid

5: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; zinc(II) oxide; europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; In tetrahydrofuran; acetone; toluene; acetonitrile; 3: |Michael Addition;
DOI:10.1021/ol400136y