(S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate
CAS No.:1281895-48-4
Molecular Formula:C₂₇H₄₂N₂O₉
Molecular Weight:538.638
Hs Code.:

Synonyms:(S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate

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Chemical Property of (S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate

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Technology Process of (S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate

There total 7 articles about (S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 1281895-12-2
pentan-3-yl 3-(3,4-dimethoxyphenyl)-2-methyl-3-oxopropanoate

: 1281895-48-4
(S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: With europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; In acetonitrile; at -20 ℃; for 48h; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol400136y

Reference yield:

: 1061631-11-5
pentan-3-yl 3-(3,4-dimethoxyphenyl)-3-oxopropanoate

: 1281895-48-4
(S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / 40 °C

2: europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine / acetonitrile / 48 h / -20 °C / Molecular sieve; Inert atmosphere

With potassium carbonate; europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; In acetone; acetonitrile; 2: |Michael Addition;
DOI:10.1021/ol400136y

Reference yield:

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 1281895-48-4
(S)-di-tert-butyl 1-(1-(3,4-dimethoxyphenyl)-3-(pentan-3-yloxy)-2-methyl-1,3-dioxopropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / Reflux

2: zinc(II) oxide / toluene / 24 h / Reflux

3: potassium carbonate / acetone / 24 h / 40 °C

4: europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine / acetonitrile / 48 h / -20 °C / Molecular sieve; Inert atmosphere

With sodium hydride; potassium carbonate; zinc(II) oxide; europium(III) trifluoromethanesulfonate; 2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; In tetrahydrofuran; acetone; toluene; acetonitrile; mineral oil; 4: |Michael Addition;
DOI:10.1021/ol400136y