N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

Base Information

Chemical Name:N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane
CAS No.:1332367-75-5
Molecular Formula:C₂₄H₂₃N₅O₄S
Molecular Weight:477.544
Hs Code.:

Synonyms:N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

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Chemical Property of N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

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Technology Process of N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

There total 7 articles about N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1605289-48-2
N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

: 1332367-75-5
N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

Guidance literature:: N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane; With hydrogenchloride; palladium on carbon; hydrogen; pyrographite; palladium; acetic acid; trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 1h;

With thiophosgene; In chloroform; at 20 ℃;
DOI:10.1039/c4dt00239c

Reference yield:

: 1450624-93-7
N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane

: 1332367-75-5
N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

2.1: sodium carbonate; thiophenol / tetrahydrofuran / 48 h / 60 °C

3.1: trifluoroacetic acid; hydrogenchloride; palladium on carbon; palladium; pyrographite; acetic acid; hydrogen / tetrahydrofuran / 1 h / 20 °C

3.2: 20 °C

With hydrogenchloride; palladium on carbon; hydrogen; sodium carbonate; pyrographite; palladium; acetic acid; thiophenol; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c4dt00239c

Reference yield:

: 1605289-47-1
N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

: 1332367-75-5
N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; thiophenol / tetrahydrofuran / 48 h / 60 °C

2.1: trifluoroacetic acid; hydrogenchloride; palladium on carbon; palladium; pyrographite; acetic acid; hydrogen / tetrahydrofuran / 1 h / 20 °C

2.2: 20 °C

With hydrogenchloride; palladium on carbon; hydrogen; sodium carbonate; pyrographite; palladium; acetic acid; thiophenol; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1039/c4dt00239c