N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Base Information

• Chemical Name: N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane
• CAS No.: 1605289-48-2
• Molecular Formula: C₃₁H₃₉N₅O₆
• Molecular Weight: 577.681
• Mol file: 1605289-48-2.mol

Synonyms:N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Chemical Property of N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

There total 6 articles about N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1605289-47-1) → N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1605289-48-2)

Guidance literature:

With sodium carbonate; thiophenol; In tetrahydrofuran; at 60 ℃; for 48h;

DOI:10.1039/c4dt00239c

Reference yield:

N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane (1450624-93-7) → N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1605289-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

2: sodium carbonate; thiophenol / tetrahydrofuran / 48 h / 60 °C

With sodium carbonate; thiophenol; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/c4dt00239c

Reference yield:

6-methyl-2-pyridinecarboxylic acid (934-60-1) → N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1605289-48-2)

Guidance literature:

Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate / dichloromethane / 20 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux

3: sodium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

4: sodium carbonate; thiophenol / tetrahydrofuran / 48 h / 60 °C

With N-Bromosuccinimide; boron trifluoride diethyl etherate; sodium carbonate; thiophenol; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c4dt00239c

upstream raw materials:

N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane

N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

6-methyl-2-pyridinecarboxylic acid

tert-butyl 6-(methyl)picolinate

Downstream raw materials:

N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

N,N′-[(carboxylato)methyl]-N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

N,N′-[(tert-butoxycarbonyl)methyl]-N,N′-[[(6-tert-butoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane